| ROUND 1 | TOP | |||
| Fri Nov 11 2011 | Racing Metro 92 | 20 | Cardiff Blues | 26 |
| Fri Nov 11 2011 | Harlequins | 25 | Connacht Rugby | 17 |
| Sat Nov 12 2011 | Munster Rugby | 23 | Northampton Saints | 21 |
| Sat Nov 12 2011 | Scarlets | 31 | Castres Olympique | 23 |
| Sat Nov 12 2011 | London Irish | 19 | Edinburgh Rugby | 20 |
| Sat Nov 12 2011 | Montpellier | 16 | Leinster Rugby | 16 |
| Sat Nov 12 2011 | Aironi Rugby | 12 | Leicester Tigers | 28 |
| Sat Nov 12 2011 | Ulster Rugby | 16 | ASM Clermont Auvergne | 11 |
| Sat Nov 12 2011 | Ospreys | 28 | Biarritz Olympique | 21 |
| Sun Nov 13 2011 | Glasgow Warriors | 26 | Bath Rugby | 21 |
| Sun Nov 13 2011 | Saracens | 42 | Benetton Treviso | 17 |
| Sun Nov 13 2011 | Toulouse | 21 | Gloucester Rugby | 17 |
| ROUND 2 | TOP | |||
| Fri Nov 18 2011 | Northampton Saints | 23 | Scarlets | 28 |
| Fri Nov 18 2011 | Cardiff Blues | 24 | London Irish | 18 |
| Fri Nov 18 2011 | Edinburgh Rugby | 48 | Racing Metro 92 | 47 |
| Fri Nov 18 2011 | ASM Clermont Auvergne | 54 | Aironi Rugby | 3 |
| Sat Nov 19 2011 | Castres Olympique | 24 | Munster Rugby | 27 |
| Sat Nov 19 2011 | Leicester Tigers | 20 | Ulster Rugby | 9 |
| Sat Nov 19 2011 | Benetton Treviso | 26 | Ospreys | 26 |
| Sat Nov 19 2011 | Biarritz Olympique | 15 | Saracens | 10 |
| Sat Nov 19 2011 | Connacht Rugby | 10 | Toulouse | 36 |
| Sat Nov 19 2011 | Gloucester Rugby | 9 | Harlequins | 28 |
| Sun Nov 20 2011 | Bath Rugby | 16 | Montpellier | 13 |
| Sun Nov 20 2011 | Leinster Rugby | 38 | Glasgow Warriors | 13 |
| ROUND 3 | TOP | |||
| Fri Dec 9 2011 | Cardiff Blues | 25 | Edinburgh Rugby | 8 |
| Fri Dec 9 2011 | Ulster Rugby | 31 | Aironi Rugby | 10 |
| Fri Dec 9 2011 | Harlequins | 10 | Toulouse | 21 |
| Sat Dec 10 2011 | Castres Olympique | 41 | Northampton Saints | 22 |
| Sat Dec 10 2011 | Scarlets | 14 | Munster Rugby | 17 |
| Sat Dec 10 2011 | Racing Metro 92 | 14 | London Irish | 34 |
| Sat Dec 10 2011 | Benetton Treviso | 30 | Biarritz Olympique | 26 |
| Sat Dec 10 2011 | Saracens | 31 | Ospreys | 26 |
| Sat Dec 10 2011 | Connacht Rugby | 10 | Gloucester Rugby | 14 |
| Sun Dec 11 2011 | Bath Rugby | 13 | Leinster Rugby | 18 |
| Sun Dec 11 2011 | Glasgow Warriors | 20 | Montpellier | 15 |
| Sun Dec 11 2011 | ASM Clermont Auvergne | 30 | Leicester Tigers | 12 |
| ROUND 4 | TOP | |||
| Fri Dec 16 2011 | Edinburgh Rugby | 19 | Cardiff Blues | 12 |
| Fri Dec 16 2011 | Biarritz Olympique | 29 | Benetton Treviso | 12 |
| Fri Dec 16 2011 | Ospreys | 13 | Saracens | 16 |
| Sat Dec 17 2011 | London Irish | 19 | Racing Metro 92 | 25 |
| Sat Dec 17 2011 | Leinster Rugby | 52 | Bath Rugby | 27 |
| Sat Dec 17 2011 | Montpellier | 13 | Glasgow Warriors | 13 |
| Sat Dec 17 2011 | Aironi Rugby | 20 | Ulster Rugby | 46 |
| Sat Dec 17 2011 | Leicester Tigers | 23 | ASM Clermont Auvergne | 19 |
| Sat Dec 17 2011 | Gloucester Rugby | 23 | Connacht Rugby | 19 |
| Sun Dec 18 2011 | Munster Rugby | 19 | Scarlets | 13 |
| Sun Dec 18 2011 | Northampton Saints | 45 | Castres Olympique | 0 |
| Sun Dec 18 2011 | Toulouse | 24 | Harlequins | 31 |
| ROUND 5 | TOP | |||
| Fri Jan 13 2012 | Racing Metro 92 | 24 | Edinburgh Rugby | 27 |
| Fri Jan 13 2012 | Ospreys | 44 | Benetton Treviso | 17 |
| Fri Jan 13 2012 | Ulster Rugby | 41 | Leicester Tigers | 7 |
| Sat Jan 14 2012 | Munster Rugby | 26 | Castres Olympique | 10 |
| Sat Jan 14 2012 | Scarlets | 17 | Northampton Saints | 29 |
| Sat Jan 14 2012 | Aironi Rugby | 0 | ASM Clermont Auvergne | 82 |
| Sat Jan 14 2012 | London Irish | 15 | Cardiff Blues | 22 |
| Sat Jan 14 2012 | Montpellier | 24 | Bath Rugby | 22 |
| Sat Jan 14 2012 | Harlequins | 20 | Gloucester Rugby | 14 |
| Sat Jan 14 2012 | Toulouse | 24 | Connacht Rugby | 3 |
| Sun Jan 15 2012 | Saracens | 20 | Biarritz Olympique | 16 |
| Sun Jan 15 2012 | Glasgow Warriors | 16 | Leinster Rugby | 23 |
| ROUND 6 | TOP | |||
| Fri Jan 20 2012 | Connacht Rugby | 9 | Harlequins | 8 |
| Fri Jan 20 2012 | Gloucester Rugby | 34 | Toulouse | 24 |
| Sat Jan 21 2012 | Bath Rugby | 23 | Glasgow Warriors | 18 |
| Sat Jan 21 2012 | Leinster Rugby | 25 | Montpellier | 3 |
| Sat Jan 21 2012 | Castres Olympique | 13 | Scarlets | 16 |
| Sat Jan 21 2012 | Northampton Saints | 36 | Munster Rugby | 51 |
| Sat Jan 21 2012 | ASM Clermont Auvergne | 19 | Ulster Rugby | 15 |
| Sat Jan 21 2012 | Leicester Tigers | 33 | Aironi Rugby | 6 |
| Sun Jan 22 2012 | Cardiff Blues | 36 | Racing Metro 92 | 30 |
| Sun Jan 22 2012 | Edinburgh Rugby | 34 | London Irish | 11 |
| Sun Jan 22 2012 | Benetton Treviso | 20 | Saracens | 26 |
| Sun Jan 22 2012 | Biarritz Olympique | 36 | Ospreys | 5 |
| Quarter-Finals | TOP | |||
| Fri Apr 6 2012 | Munster Rugby | Ulster Rugby | ||
| Sat Apr 7 2012 | Leinster Rugby | Cardiff Blues | ||
| Sun Apr 8 2012 | Edinburgh Rugby | Toulouse | ||
| Sun Apr 8 2012 | Saracens | ASM Clermont Auvergne | ||
| Semi-Finals | TOP | |||
| Fri Apr 27 2012 | QF Winner 1 | QF Winner 3 | ||
| Sat Apr 28 2012 | QF Winner 2 | QF Winner 4 | ||
| FINAL | TOP | |||
| Sun May 20 2012 | SF Winner 1 | SF Winner 2 | ||